Three-way ball valves have an L- or T-shaped hole through the middle. The different combinations of flow are shown in the figure. It is easy to see that a T valve can connect any pair of ports, or all three, together, but the 45 degree position which might disconnect all three leaves no margin for error. The L valve can connect the center port to either side port, or disconnect all three, but it cannot connect the side ports together.

Multi-port ball valves with 4 ways, or more, are also commercially available, the inlet way often being orthogonal to the plane of the outlets. For special applications, such as driving air-powered motors from forward to reverse, the operation is performed by rotating a single lever four-way valve. The 4-way ball valve has two L-shaped ports in the ball that do not interconnect, sometimes referred to as an "×" port.

Ball valves in sizes up to 2 inch generally come in single piece, two or three piece designs. One piece ball valves are almost always reduced bore, are relatively inexpensive and generally are throw-away. Two piece ball valves are generally slightly reduced (or standard) bore, they can be either throw-away or repairable. The 3 piece design allows for the center part of the valve containing the ball, stem & seats to be easily removed from the pipeline. This facilitates efficient cleaning of deposited sediments, replacement of seats and gland packings, polishing out of small scratches on the ball, all this without removing the pipes from the valve body. The design concept of a three piece valve is for it to be repairable..